Published April 1997
| public
Journal Article
A glucose-sensing polymer
Chicago
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Abstract
We have prepared a robust polymer that can be used to measure glucose concentrations in complex biological media. At alkaline pH, the metal-complexing polymer binds glucose and instantly releases protons in proportion to the glucose concentration over a clinically relevant range (0 to 25 mM). The inexpensive polymer is sufficiently selective to provide an easily measurable response to glucose in porcine plasma. The polymer's ability to function at nonphysiological pH (at which the buffer capacity of biological samples is small) makes it possible to design simple and inexpensive sensing devices based on measurement of changes in proton concentration.
Additional Information
© 1997 Nature Publishing Group. Received 17 December 1996; accepted 11 February 1997. This research was supported in part by the US National Science Foundation. GC is supported by a postdoctoral fellowship from the NIGMS.Additional details
- Eprint ID
- 58352
- DOI
- 10.1038/nbt0497-354
- Resolver ID
- CaltechAUTHORS:20150618-141848730
- NSF
- NIH Postdoctoral Fellowship
- Created
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2015-06-18Created from EPrint's datestamp field
- Updated
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2021-11-10Created from EPrint's last_modified field