Neuroactive chondroitin sulfate glycomimetics
Abstract
We report the generation of chondroitin sulfate (CS) glycomimetics with tunable chemical and biological properties. Our approach greatly simplifies the synthesis of complex glycosaminoglycans, providing synthetically accessible, bioactive structures of programmable sulfation sequence. Using these glycopolymers, we demonstrate that multivalent interactions are critical for modulating CS activity and discover an unexpected tolerance for unnatural polymeric architectures. We envision that these glycomimetics will facilitate further explorations into the influence of macromolecular structure on glycosaminoglycan function and provide powerful tools for manipulating CS activity in vivo.
Additional Information
© 2008 American Chemical Society. ACS AuthorChoice. Received November 5, 2007. We thank Prof. Robert H. Grubbs, Dr. Jason P. Jordon, and Dr. Erin Guidry for generous donation of the water-soluble catalyst and for helpful discussions. This work was supported by the American Cancer Society (Grant RSG-05-106-01-CDD), Tobacco-Related Disease Research Program (14RT-0034), and the Howard Hughes Medical Institute.Attached Files
Published - ja709993p.pdf
Supplemental Material - ja709993p-file003.pdf
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Additional details
- PMCID
- PMC3034635
- Eprint ID
- 57657
- Resolver ID
- CaltechAUTHORS:20150519-110827039
- RSG-05-106-01-CDD
- American Cancer Society
- 14RT-0034
- California Tobacco-Related Disease Research Program
- Howard Hughes Medical Institute (HHMI)
- Created
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2015-05-19Created from EPrint's datestamp field
- Updated
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2021-11-10Created from EPrint's last_modified field