Published June 4, 2003
| Supplemental Material
Journal Article
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Dynamic glycosylation of the transcription factor CREB: A potential role in gene regulation
Abstract
We report that CREB (cyclic AMP-responsive element-binding protein), a transcription factor essential for long-term memory, is O-GlcNAc glycosylated in the mammalian brain. Glycosylation occurs at two sites within the Q2 domain and disrupts the interaction between CREB and TAF_(II)130, thereby repressing the transcriptional activity of CREB in vitro. These findings have important implications for the role of O-GlcNAc glycosylation in gene regulation, and they provide a link between O-GlcNAc and information storage processes in the brain.
Additional Information
© 2003 American Chemical Society. Received August 19, 2002. We thank C. Gama, N. Khidekel, M. Shahgholi, and P. Snow for invaluable assistance, and R. Goodman, J. Hanover, and N. Tanese for providing cDNAs. We also gratefully acknowledge support from the Research Corporation and Beckman Young Investigators Program.Attached Files
Supplemental Material - ja028200tsi20030418_012614_si.pdf
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Additional details
- Eprint ID
- 57654
- Resolver ID
- CaltechAUTHORS:20150519-103941237
- Research Corporation
- Arnold and Mabel Beckman Foundation
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2015-05-19Created from EPrint's datestamp field
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2021-11-10Created from EPrint's last_modified field