Published February 9, 2005
| Supplemental Material
Journal Article
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A Role for Fucose α(1−2) Galactose Carbohydrates in Neuronal Growth
Abstract
We report a fucose α(1−2) galactose-mediated pathway for the modulation of neuronal growth and morphology. Our studies provide strong evidence for the presence of Fucα(1−2)Gal glycoproteins and lectin receptors in hippocampal neurons. Additionally, we show that manipulation of Fucα(1−2)Gal-associated proteins using small-molecule and lectin probes induces dramatic changes in neuronal morphology. These findings may provide a novel pathway to stimulate neuronal growth and regeneration.
Additional Information
© 2005 American Chemical Society. Received September 3, 2004. We thank the Biological Imaging Center at Caltech for instrumentation. This research was supported by an NIH Training Grant (T32 GM08501), NIH (RO1 NS045061), and the Alfred P. Sloan Foundation.Attached Files
Supplemental Material - ja044631vsi20041109_053635_si.pdf
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Additional details
- Eprint ID
- 57652
- Resolver ID
- CaltechAUTHORS:20150519-101948364
- T32 GM08501
- NIH Predoctoral Fellowship
- RO1 NS045061
- NIH
- Alfred P. Sloan Foundation
- Created
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2015-05-19Created from EPrint's datestamp field
- Updated
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2021-11-10Created from EPrint's last_modified field