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Published August 6, 1992 | public
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The gene lin-3 encodes an inductive signal for vulval development in C. elegans

Hill, Russell J.
Sternberg, Paul W. ORCID icon
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Abstract

The lin-3 gene is necessary for induction of the Caenorhabditis elegans vulva by the anchor cell. It encodes a molecule similar to epidermal growth factor and to transforming growth factor-a and acts through the epidermal growth factor receptor homologue let-23. Expression of lin-3 in the anchor cell stimulates vulval induction; lin-3 may encode the vulval inducing signal.

Additional Information

© 1992 Nature Publishing Group. Received 7 May: accepted 25 June 1992. We thank P. Tzou for technical assistance, A. Coulson and J. Sulston for the λ2001 genomic library and cosmids near the lin-3 locus; R. Waterston for YAC clones grids; I. Mori for RW7096; M. Chalfie for TU355; A. Rose and O. Bailie for map data; A. Fire for lacZ expression vectors and protocols; R. Barstead, C. Martin and S. Kim for cDNA libraries; P. Bjorkman. L. Kozar and E. Schwarz for help with sequence analysis; L. Carta and L. Huang for sharing unpublished results; and members of our laboratory, O. Anderson and E. Schwarz for their comments on the manuscript. This work was supported by a USPHS grant and a Searle Scholar Award to P.W.S. P.W.S. is an investigator of the Howard Hughes Medical Institute. R.J.H. was an NSF predoctoral fellow.

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August 20, 2023
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October 23, 2023