Published 1992
| public
Book Section - Chapter
Synthetic metalloproteins
- Creators
- Tomich, John M.
- Richards, John H.
- Others:
- Smith, John A.
- Rivier, Jean E.
Chicago
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Abstract
With the success of chemical syntheses and purification of large polypeptides ( > 50 amino acid residues) attention now focuses on developing protocols to correctly fold these products to generate species with high levels of bioactivity. The art of 'breathing life' into these molecules requires denaturation/renaturation, reduction/oxidation of sulfhydryls and assembly of holoproteins from apo-forms. We outline herein some of the strategies employed to assemble metalloproteins with activities essentially identical to that of their native counterparts.
Additional Information
© 1992 ESCOM. We greatly acknowledge the participation of Dr. Takeo Iwamoto who assisted in the chemical synthesis of the polypeptides and Drs. Eugene Smith, Benjamin Feinberg, and C. Frank Shaw III who performed the biophysical characterizations.Additional details
- Eprint ID
- 57256
- Resolver ID
- CaltechAUTHORS:20150506-085259870
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2015-05-06Created from EPrint's datestamp field
- Updated
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2019-10-03Created from EPrint's last_modified field