Published October 1969
| public
Journal Article
Substrates for fumarate hydratase
- Creators
- Nigh, Wesley G.
- Richards, John H.
Abstract
Fluorofumaric acid and difluorofumaric acid are found to be substrates for fumarate hydratase. The direction of addition of water to fluorofumarate and, more importantly, the relative reactivities of fluorofumarate and difluorofumarate support a mechanism for the hydration reaction that involves a carbonium ion type intermediate. Neither 2-(S)-2-methoxysuccinic nor 2-(S)-2-acetoxysuccinic acid nor mono- or difluoromaleic acid are substrates for fumarate hydratase.
Additional Information
© 1969 American Chemical Society. Received January 10, 1969. We thank the National Institutes of Health of the U.S. Public Health Service (Grant GM-10218) for support of this research.Additional details
- Eprint ID
- 57079
- Resolver ID
- CaltechAUTHORS:20150429-084340544
- GM-10218
- NIH
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2015-05-01Created from EPrint's datestamp field
- Updated
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2021-11-10Created from EPrint's last_modified field