The Regulation and Function of NGF Receptors in Normal and Immortalized Sympathoadrenal Progenitor Cells
- Other:
- Ibáñez, C. F.
Abstract
The generation of neurons from progenitor cells is regulated at several steps, including proliferation, lineage commitment, overt differentiation and survival. Much of our current understanding of the molecular control of early stages in neurogenesis derives from experiments in invertebrate systems where mutational genetics is feasible, such as Drosophila and C. elegans (for a review, see Campos-Ortega and Jan (1)). Such studies appear to be directly extendible to vertebrate neurogenesis due to the remarkable evolutionary conservation of structure and expression pattern for many of the genes important in invertebrate neurogenesis (2-6). However, one fundamentally important aspect of vertebrate neurogenesis that is not yet adequately modeled by invertebrate genetic systems is the control of neurotrophic factor responsiveness.
Additional Information
© 1995 Pergamon Press. Some of the work described in this chapter was supported by NIH grant NS23476 and a PEW Foundation Faculty Fellowship in Neurosciences to D.J.A. We thank Nancy Ip and George Yancopoulos for communicating their unpublished data, for interesting discussions and for supplying various reagents. We also thank Adela Augsburger for her early contributions to this work and Rochelle Diamond for help with fluorescence-activated cell sorting. J.V. is supported by an individual NRSA from the NIH. S.J.B. was a research associate and D.J.A. an associate investigator of the Howard Hughes Medical Institute.Additional details
- Eprint ID
- 56702
- Resolver ID
- CaltechAUTHORS:20150416-084445211
- NS23476
- NIH
- Pew Foundation
- National Research Service Award
- Howard Hughes Medical Institute (HHMI)
- Created
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2015-04-16Created from EPrint's datestamp field
- Updated
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2020-03-09Created from EPrint's last_modified field
- Series Name
- Wenner-Gren international series
- Series Volume or Issue Number
- 67