C. elegans lin-45 raf gene participates in let-60 ras-stimulated vulval differentiation

Creators: Han, Min; Golden, Andy; Han, Yuming; Sternberg, Paul W.

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Abstract

Vulval differentiation in Caenorhabditis elegans is controlled by intercellular signalling mediated by a receptor tyrosine kinase and a ras gene product. The lin-45 gene encodes a homologue of the raf family of serine/threonine kinases and is necessary for vulval differentiation. The lin-45 raf gene product appears to act downstream of the ras protein in this pathway. A proto-oncogene-mediated signalling pathway may be a common feature of metazoan development.

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© 1993 Nature Publishing Group. We thank P. Tzou, R. Rogge, H. Mori and Y. Hajdu for technical contributions; A. Coulson and the MRC group for cosmids; R. Barstead and R. Waterston for the deb-1 strain, the cDNA library and the YAC clones; the Caltech Biopolymer Synthesis and Analysis Resource Center for oligonucleotides; N. Bonini, H. Lipshitz, M. Kennedy, A. Valsamakis, D. Weigel and members of our laboratories for discussion and editorial comments. Some nematode strains were provided by the Caenorhabditis Genetic Center, which is funded by the NIH National Center for Research Resources. M.H. thanks W. Wood for support. M.H. is a Lucille P. Markey Scholar in Biomedical Science. A. G. is a postdoctoral fellow of the USPHS. P.W.S. is an investigator of the Howard Hughes Medical Institute. This research has been supported by US Public Health Service grants to M.H. and to P.W.S., and has been partly supported by the Lucille P. Markey Charitable Trust. GenBank Accession Number for lin-45 raf is L15347.

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C. elegans lin-45 raf gene participates in let-60 ras-stimulated vulval differentiation

Abstract

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