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Published June 13, 1991 | public
Journal Article

Multiple intercellular signalling systems control the development of the Caenorhabditis elegans vulva

Abstract

Developmental, genetic and molecular studies indicate that multiple intercellular signalling systems interact to specify the types and spatial patterns of cells generated during the formation of the vulva of the nematode Caenorhabditis elegans. Two classes of evolutionary conserved transmembrane receptors and a Ras protein function in these signalling systems. The biology of vulval development provides a framework for understanding how cell interactions control the development of animals as diverse as nematodes, insects and mammals.

Additional Information

© 1991 Nature Publishing Group. We thank the members of our laboratories, particularly C. Bargmann and E. Jorgensen. and L. Avery, M. Chalfie. E. Davidson. C. Ferguson, I. Greenwald, B. Herman, I. Herskowltz, C. Kenyon. S. Kim, J. Kimble, K. Struhl and J. White for many helpful suggestions. The work done in our laboratories was supported by the US Public Health Service. H.R.H. and P.W.S. are Investigators of the Howard Hughes Medical Institute.

Additional details

Created:
August 20, 2023
Modified:
October 23, 2023