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Published January 28, 2015 | Published
Journal Article Open

Gene Ontology Consortium: going forward

Blake, J. A.
Chan, J. ORCID icon
Kishore, R.
Sternberg, P. W. ORCID icon
Van Auken, K. ORCID icon
Müller, H. M.
Done, J.
Li, Y.

Abstract

The Gene Ontology (GO; http://www.geneontology.org) is a community-based bioinformatics resource that supplies information about gene product function using ontologies to represent biological knowledge. Here we describe improvements and expansions to several branches of the ontology, as well as updates that have allowed us to more efficiently disseminate the GO and capture feedback from the research community. The Gene Ontology Consortium (GOC) has expanded areas of the ontology such as cilia-related terms, cell-cycle terms and multicellular organism processes. We have also implemented new tools for generating ontology terms based on a set of logical rules making use of templates, and we have made efforts to increase our use of logical definitions. The GOC has a new and improved web site summarizing new developments and documentation, serving as a portal to GO data. Users can perform GO enrichment analysis, and search the GO for terms, annotations to gene products, and associated metadata across multiple species using the all-new AmiGO 2 browser. We encourage and welcome the input of the research community in all biological areas in our continued effort to improve the Gene Ontology.

Additional Information

© The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. Received September 24, 2014; Revised October 30, 2014; Accepted October 31, 2014. Published online 26 November 2014. We gratefully acknowledge the many other contributors to GO annotation efforts: Gramene, Department of Botany and Plant Pathology, Oregon State University, Corvallis, OR, USA; The J. Craig Venter Institute, Rockville, MD, USA; PAMGO, Wells College, Aurora, NY, USA and PAMGO, Virginia Bioinformatics Institute, VA, USA; AspGD, Stanford, CA, USA; CGD, Stanford, CA, USA; Sanger GeneDB, Hinxton, UK; InterPro European Molecular Biology Laboratory-European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, UK; IntAct, (EMBL-EBI), Hinxton, UK; seudo- CAP, British Columbia, Canada; SGN, Ithaca, NY, USA. Funding: National Institutes of Health/National Human Genome Research Institute grant [HG002273] awarded to the PI group formed by Judith A. Blake, J. Michael Cherry, Suzanna E. Lewis, PaulW. Sternberg, and Paul D. Thomas, as well as additional funding awarded to each participating institution. For more details please visit: http: //geneontology.org/page/go-consortium-contributors-list. Funding for open access charge: National Institutes of Health/National Human Genome Research Institute [HG002273].

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Additional details

Identifiers Funding Dates
Created:
August 20, 2023
Modified:
October 23, 2023