Published May 15, 1975
| public
Journal Article
Molecular Basis for the α_1-Protease Inhibitor Deficiency
- Creators
- Chan, S. K.
-
Rees, D. C.
Chicago
An error occurred while generating the citation.
Abstract
The α_1-protease inhibitor (formerly α1-antitrypsin) is in herited by a series of autosomal codominant alleles that determine its concentration and electrophoretic mobility. Serum from individuals with severe α1-protease inhibitor deficiency usually contains an electrophoretically slow-moving α_1-protease inhibitor (type ZZ) in an amount 10–40% of that found in the normal population (type MM). This deficient state is associated with either an early-onset form of familial emphysema or familial infantile cirrhosis.
Additional Information
© 1975 Nature Publishing Group. Received January 27; revised April 2, 1975. This research was supported by a grant from the National Institutes of Health. We thank Drs R. Talamo and J. Pierce for performing the electrophoresis in their laboratories and for providing serum from ZZ individuals.Additional details
- Eprint ID
- 54661
- Resolver ID
- CaltechAUTHORS:20150210-100937554
- NIH
- Created
-
2015-02-11Created from EPrint's datestamp field
- Updated
-
2021-11-10Created from EPrint's last_modified field