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Published May 12, 1982 | public
Book Section - Chapter

Interaction of Synthetic Polymers with Cell Membranes and Model Membrane Systems IV. Pyran Copolymer

Abstract

We have investigated the interaction of pyran copolymer with erythrocyte ghosts, with intact erythrocytes and with liposomes of pure dipalmitoylphosphatidylcholine (DPPC). Particular attention was given to the importance of divalent metals (especially Ca^(2+)) in promoting the association of pyran copolymer with cell and lipid surfaces. High sensitivity differential scanning calorimetry shows: i) The perturbation of erythrocyte ghost structure by pyran copolymer is not reidily 'bashed out" by treatment with fresh buffer, ii) This perturbation is not due simply to sequestration of metal ions, iii) Pyran copolymer reverses at least partially the effects of Ca^(2+) added to erythrocyte ghosts, and iv) Pyran copolymer raises the transition temperature of DPPC liposomes in the presence of 5 mM Ca^(2+), but not in the absence of added Ca^(2+).

Additional Information

© 1982 American Chemical Society. The authors would like to thank Professors William S. Kelley and James F. Williams for use of liquid scintillation counters. This work was supported by the Health Research and Services Foundation, Pittsburgh, PA., and by the Samuel and Emma Winters Foundation. The calorimeter was purchased with the aid of National Science Foundation Grant No.. CHE-79-11206.

Additional details

Created:
August 19, 2023
Modified:
January 13, 2024