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Published 1993 | Published
Book Section - Chapter Open

Synthesis and Characterization of Periodic Polypeptides Containing Repeating —(AlaGly)_xGluGly— Sequences

Abstract

We have expressed in E. coli a series of periodic polypeptides represented by sequence 1. Our objective has been an understanding of the role of chemical sequence in determining the chain folding behavior of periodic macromolecules. Molecular organization has been examined by infrared spectroscopy and ^1H and ^(13)C NMR methods and a preliminary model of the folded structure has been developed.

Additional Information

© Materials Research Society 1993. This work was supported by a grant from the Polymers and Genetics Programs of the National Science Foundation (DMR-8914359) and by the Materials Research Laboratory at the University of Massachusetts. J. Borbély thanks the Fulbright Foundation for financial support. Dr. Borbély is on leave from the Department of Applied Chemistry, Kossuth Lajos University, H-40 10 Debrecen, Hungary. Yoshikuni Deguchi was on leave from Central Research Laboratories, Kaneka Corporation, 1-2-80, Yoshida-cho, Hyogo-ku, Kobe 652, JAPAN.

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