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Published August 23, 1985 | public
Journal Article

Nucleotide sequence of yellow fever virus: implications for flavivirus gene expression and evolution

Abstract

The sequence of the entire RNA genome of the type flavivirus, yellow fever virus, has been obtained. Inspection of this sequence reveals a single long open reading frame of 10,233 nucleotides, which could encode a polypeptide of 3411 amino acids. The structural proteins are found within the amino-terminal 780 residues of this polyprotein; the remainder of the open reading frame consists of nonstructural viral polypeptides. This genome organization implies that mature viral proteins are produced by posttranslational cleavage of a polyprotein precursor and has implications for flavivirus RNA replication and for the evolutionary relation of this virus family to other RNA viruses.

Additional Information

© 1985 American Association for the Advancement of Science. 17 May 1985; Accepted 7 July 1985. We thank E. G. Strauss, L. Dalgarno, and C. Chang for helpful discussions and our many colleagues for critical comments on the manuscript; L. Hood and T. Hunkapiller for the use of their computer facilities; and C. S. Hahn for help with RNA secondary structure analysis. We also thank G. Cleaves, J. J . Schlesinger, and F. X. Heinz for allowing us to quote their unpublished results. Supported in part by grants AI 20612 and AI 10793 from NIH and by grant PCM 83-16856 from NSF.

Additional details

Created:
August 19, 2023
Modified:
October 20, 2023