Published January 1, 2015
| public
Journal Article
Not Second Class: The First Class II MHC Crystal Structure
- Creators
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Bjorkman, Pamela J.
Abstract
Classical MHC proteins come in two flavors: class I and class II. In some ways, it can seem that class I MHC molecules have lots of advantages over class II: class I molecules are expressed on almost all cells instead of just a subset of immune cells and are recognized by exciting and dangerous "killer" T cells, whereas class II molecules are targeted by seemingly more benign "helper" T cells. However, class II MHC molecules have their own story to tell, and the first crystal structure of a class II MHC protein (1), solved in 1993, was no exception.
Additional Information
© 2014 by The American Association of Immunologists, Inc. The author has no financial conflicts of interest.Additional details
- Eprint ID
- 53147
- DOI
- 10.4049/jimmunol.1402828
- Resolver ID
- CaltechAUTHORS:20141223-105820003
- Created
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2014-12-23Created from EPrint's datestamp field
- Updated
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2021-11-10Created from EPrint's last_modified field