Published June 15, 1992
| Published
Journal Article
Open
Eight base changes are sufficient to convert a leucine-inserting tRNA into a serine-inserting tRNA
- Creators
- Normanly, Jennifer
- Ollick, Tracy
- Abelson, John
Chicago
An error occurred while generating the citation.
Abstract
Each aminoacyl-tRNA synthetase must functionally distinguish its cognate tRNAs from all others. We have determined the minimum number of changes required to transform a leucine amber suppressor tRNA to serine identity. Eight changes are required. These are located in the acceptor stem and in the D stem.
Additional Information
© National Academy of Sciences. Contributed by John Abelson, February 26, 1992. We acknowledge with thanks the perceptive advice of Margaret Saks and Jeffrey Sampson in preparation of the manuscript. We also thank Haul Wong and David Teplow of the California Institute of Technology Microchemical Facility and Lynn Williams and Jolene Omiya of the University of Southern California Core Microchemical Laboratory for protein sequencing. This research was supported by grants from Office of Naval Research (N00014-86-K-0755) and National Institutes of Health (GM32637).Attached Files
Published - PNAS-1992-Normanly-5680-4.pdf
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PNAS-1992-Normanly-5680-4.pdf
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Additional details
- PMCID
- PMC49356
- Eprint ID
- 52889
- Resolver ID
- CaltechAUTHORS:20141216-141202011
- Office of Naval Research (ONR)
- N00014-86-K-0755
- NIH
- GM32637
- Created
-
2014-12-16Created from EPrint's datestamp field
- Updated
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2021-11-10Created from EPrint's last_modified field