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Published August 2003 | public
Journal Article

Structure and Mechanism in Prokaryotic Mechanosensitive Channels

Abstract

Mechanosensitive channels function as electromechanical switches with the capability to sense the physical state of lipid bilayers. The X-ray crystal structures of MscL and MscS offer a unique opportunity to identify the types of protein motions associated with the opening and closing of these structurally unrelated channels, while providing the framework to address a mechanism of tension sensing that is defined by channel–lipid interactions. Recent functional, structural and dynamic data offer fresh insights into the molecular basis of gating for these membrane proteins.

Additional Information

© 2003 Elsevier.

Additional details

Created:
August 19, 2023
Modified:
October 18, 2023