The Structures of BtuCD and MscS and their Implications for Transporter and Channel Function
Abstract
The passage of most molecules across biological membranes is mediated by specialized integral membrane proteins known as channels and transporters. Although these transport families encompass a wide range of functions, molecular architectures and mechanisms, there are common elements that must be incorporated within their structures, namely the translocation pathway, ligand specificity elements and regulatory sensors to control the rate of ligand £ow across the membrane. This minireview discusses aspects of the structure and mechanism of two bacterial transport systems, the stretch-activated mechanosensitive channel of small conductance (MscS) and the ATP-dependent vitamin B12 uptake system (BtuCD), emphasizing their general implications for transporter function.
Additional Information
© 2003 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. Received 25 August 2003; accepted 1 September 2003 Research in the authors' lab was supported in part by the US National Institutes of Health, grant GM62532, to D.C.R. and a postdoctoral fellowship to R.B.B.Additional details
- Eprint ID
- 52784
- DOI
- 10.1016/S0014-5793(03)01126-8
- Resolver ID
- CaltechAUTHORS:20141212-144942986
- NIH
- GM62532
- Created
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2014-12-22Created from EPrint's datestamp field
- Updated
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2021-11-10Created from EPrint's last_modified field