Published October 2013
| public
Book Section - Chapter
A Handheld Magnetic Sensing Platform for Antigen And Nucleic Acid Detection
Chicago
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Abstract
The core requirements for point-of-care (POC) diagnostics necessitate low-cost, high multiplexing, portability, easily integrated sample preparation, and quick measurement time [1, 2]. Frequency-shift based magnetic sensing is a measurement technique utilizing a complementary metal-oxide-semiconductor (CMOS) integrated-circuit (IC) chip for magnetic label detection. Using this technology, we have developed a complete handheld, low-power, low-cost, disposable cartridge-based diagnostic device (Fig. 1a,b) with two fully implemented assays for antigens and nucleic acids. We have demonstrated reliable measurements down to 100 pM for a 31 base-pair oligomer and 1 pM for the protein interferon-γ (IFN-γ).
Additional Information
© 2013 CBMS. The authors would like to acknowledge Stephanie Johnson and Rob Phillips for their help in aiding DNA attachment chemistry; Habib Ahmad, Alex Sutherland and James Heath for guidance and tools in developing surface chemistry; Derek Rinderknecht and Morteza Gharib for providing high power microscopes; and members of the Caltech CHIC lab for general guidance. This research was supported by the Caltech CI2 and City of Hope grants.Additional details
- Eprint ID
- 52623
- Resolver ID
- CaltechAUTHORS:20141212-101836648
- Caltech CI2 grant
- City of Hope
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2014-12-12Created from EPrint's datestamp field
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2020-03-09Created from EPrint's last_modified field