Published March 7, 1997
| public
Journal Article
Oxidative Thymine Dimer Repair in the DNA Helix
Abstract
The metallointercalator Rh(phi)_2DMB^(3+) (phi, 9,10-phenanthrenequinone diimine; DMB, 4,4′-dimethyl-2,2′-bipyridine) catalyzed the repair of a thymine dimer incorporated site-specifically in a 16-base pair DNA duplex by means of visible light. This repair could be accomplished with rhodium noncovalently bound to the duplex and at long range (16 to 26 angstroms), with the rhodium intercalator tethered to either end of the duplex assembly. This long-range repair was mediated by the DNA helix. Repair efficiency did not decrease with increasing distance between intercalated rhodium and the thymine dimer, but it diminished with disruption of the intervening π-stack.
Additional Information
© 1997 American Association for the Advancement of Science. Received 24 July 1996; accepted 23 January 1997. Supported by NIH grant GM49216, a postdoctoral fellowship from the Cancer Research Fund of the Damon Runyon–Walter Winchell Foundation (P.J.D.), and an NSF predoctoral fellowship (R.E.H.). We thank N. J. Turro and E. D. A. Stemp for helpful discussions.Additional details
- Eprint ID
- 52179
- DOI
- 10.1126/science.275.5305.1465
- Resolver ID
- CaltechAUTHORS:20141126-103406641
- GM49216
- NIH
- Damon Runyon–Walter Winchell Foundation
- NSF predoctoral fellowship
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2014-11-27Created from EPrint's datestamp field
- Updated
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2021-11-10Created from EPrint's last_modified field