Published March 10, 2006
| Supplemental Material
Journal Article
Open
Genome-Wide Prediction of C. elegans Genetic Interactions
- Creators
- Zhong, Weiwei
-
Sternberg, Paul W.
Chicago
Abstract
To obtain a global view of functional interactions among genes in a metazoan genome, we computationally integrated interactome data, gene expression data, phenotype data, and functional annotation data from three model organisms—Saccharomyces cerevisiae, Caenorhabditis elegans, and Drosophila melanogaster—and predicted genome-wide genetic interactions in C. elegans. The resulting genetic interaction network (consisting of 18,183 interactions) provides a framework for system-level understanding of gene functions. We experimentally tested the predicted interactions for two human disease-related genes and identified 14 new modifiers.
Additional Information
© 2006 American Association for the Advancement of Science. 1 December 2005; Accepted 26 January 2006. We thank the Caenorhabditis Genetics Center for strains; WormBase staff for discussions; L. Chen for advice on statistical analysis; B. Perry for maintaining reagents; and C. Van Buskirk, E. Hallem, B. Hwang, M. Kato, E. Kipreos, R. Kishore, A. Petcherski, and E. Schwarz for critical reading of the manuscript. P.W.S. is an investigator and W.Z. is an associate of the Howard Hughes Medical Institute.Attached Files
Supplemental Material - ZhongW.SOM.pdf
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Additional details
- Eprint ID
- 51980
- DOI
- 10.1126/science.1123287
- Resolver ID
- CaltechAUTHORS:20141119-151713868
- Howard Hughes Medical Institute (HHMI)
- Created
-
2014-11-20Created from EPrint's datestamp field
- Updated
-
2021-11-10Created from EPrint's last_modified field