Varshavsky's Contributions

Abstract

We are writing to express our enthusiasm that the discovery of the ubiquitin conjugation system has been acknowledged with the award of the Nobel Prize in Chemistry to three outstanding biochemists: Avram Hershko and Aaron Ciechanover of the Technion Institute in Israel, and Irwin Rose of the University of California at Irvine ("Gold medal from cellular trash," G. Vogel, News Focus, 15 Oct., p. 400). Unraveling the chemistry that underlies the attachment of ubiquitin to proteins that are destined to be degraded was a magnificent achievement and is fully deserving of this recognition.

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