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Published March 24, 2000 | public
Journal Article

A Brief History of Drosophila's Contributions to Genome Research

Abstract

The sequence of the Drosophila melanogaster genome presented in this issue of Science is the latest milestone in nine decades of research on this organism. Genetic and physical mapping, whole-genome mutational screens, and functional alteration of the genome by gene transfer were pioneered in metazoans with the use of this small fruit fly. Here we look at some of the instances in which work on Drosophila has led to major conceptual or technical breakthroughs in our understanding of animal genomes.

Additional Information

2000 American Association for the Advancement of Science. We thank our many colleagues for sharing their recollections, for checking facts in their old lab notebooks, and for helpful comments on the manuscript. Supported by grant HD06331 to E.L. from NIH.

Additional details

Created:
August 19, 2023
Modified:
October 18, 2023