Published July 28, 2000
| public
Journal Article
Dependence of Stem Cell Fate in Arabidopsis on a Feedback Loop Regulated by CLV3 Activity
Abstract
The fate of stem cells in plant meristems is governed by directional signaling systems that are regulated by negative feedback. In Arabidopsis thaliana, the CLAVATA(CLV) genes encode the essential components of a negative, stem cell–restricting pathway. We used transgenic plants overexpressing CLV3 to show that meristem cell accumulation and fate depends directly on the level of CLV3 activity and that CLV3 signaling occurs exclusively through a CLV1/CLV2 receptor kinase complex. We also demonstrate that the CLV pathway acts by repressing the activity of the transcription factor WUSCHEL, an element of the positive, stem cell–promoting pathway.
Additional Information
© 2000 American Association for the Advancement of Science. Received for publication 13 April 2000. Accepted for publication 1 June 2000. We thank N. Beinert and J. Wong for technical assistance and members of the Meyerowitz lab and the Simon lab for discussion. Supported by the NIH ( J.C.F.), the U.S. Department of Agriculture ( J.C.F.), the NSF (E.M.M.), Zeneca Seeds (E.M.M.), and the Deutsche Forschungsgemeinschaft through the Sonderforschungsbereich 243 (U.B., M.H., and R.S.).Additional details
- Eprint ID
- 51681
- DOI
- 10.1126/science.289.5479.617
- Resolver ID
- CaltechAUTHORS:20141112-145026470
- NIH
- U.S. Department of Agriculture
- NSF
- Zeneca Seeds
- 243
- Deutsche Forschungsgemeinschaft (DFG)
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2014-11-13Created from EPrint's datestamp field
- Updated
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2021-11-10Created from EPrint's last_modified field