Single-Cell Responses to Face Adaptation in the Human Medial Temporal Lobe
Abstract
We used a face adaptation paradigm to bias the perception of ambiguous images of faces and study how single neurons in the human medial temporal lobe (MTL) respond to the same images eliciting different percepts. The ambiguous images were morphs between the faces of two familiar individuals, chosen because at least one MTL neuron responded selectively to one but not to the other face. We found that the firing of MTL neurons closely followed the subjects' perceptual decisions—i.e., recognizing one person or the other. In most cases, the response to the ambiguous images was similar to the one obtained when showing the pictures without morphing. Altogether, these results show that many neurons in the medial temporal lobe signal the subjects' perceptual decisions rather than the visual features of the stimulus.
Additional Information
© 2014 The Authors This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/). Accepted: August 29, 2014; Published: September 25, 2014. Available online 25 September 2014. We thank all patients for their participation and E. Behnke, T. Fields, A. Postolova, and K. Laird for technical assistance. This work was supported by grants from NINDS, EPSRC, MRC, the NIMH, and the G. Harold & Leila Y. Mathers Charitable Foundation. Author Contributions: C.K., I.F., A.K., and R.Q.Q. designed the paradigm; I.F. performed the surgeries; A.K. and F.M. collected the electrophysiological data; R.Q.Q. analyzed the data and wrote the paper; and all authors discussed the results and commented on the manuscript. R.Q.Q. and A.K. contributed equally to the study.Attached Files
Published - 1-s2.0-S0896627314007946-main.pdf
Supplemental Material - mmc1.pdf
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Additional details
- PMCID
- PMC42106374
- Eprint ID
- 50231
- DOI
- 10.1016/j.neuron.2014.09.006
- Resolver ID
- CaltechAUTHORS:20141007-105137786
- National Institute of Neurological Disorders and Stroke (NINDS)
- Engineering and Physical Sciences Research Council (EPSRC)
- Medical Research Council (UK)
- National Institute of Mental Health (NIMH)
- G. Harold and Leila Y. Mathers Charitable Foundation
- NIH
- Created
-
2014-10-09Created from EPrint's datestamp field
- Updated
-
2021-11-10Created from EPrint's last_modified field
- Caltech groups
- Koch Laboratory (KLAB)