Published November 18, 2014
| Published
Journal Article
Open
A cytotoxic and cytostatic gold(III) corrole
Abstract
We have synthesized and characterized a water-soluble gold(III) corrole (1-Au) that is highly toxic to cisplatin-resistant cancer cells. Relative to its 1-Ga analogue, axial ligands bind only weakly to 1-Au, which likely accounts for its lower affinity for human serum albumin (HSA). We suggest that the cytotoxicity of 1-Au may be related to this lower HSA affinity.
Additional Information
© 2014 The Royal Society of Chemistry. Received 21st August 2014, Accepted 4th September 2014, First published online 05 Sep 2014. We thank Roger E. Moore of the Mass Spectrometry and Proteomics Core (City of Hope) for technical assistance. Our work is supported by the Caltech-City of Hope Biomedical Research Initiative (H.B.G., J.T., Z.G.) and the Caltech Summer Undergraduate Research Fellowship program (D.R.T.).Attached Files
Published - c4cc06577h.pdf
Files
c4cc06577h.pdf
Files
(1.8 MB)
| Name | Size | Download all |
|---|---|---|
|
md5:6e4d5cff34d257880eb167f1677435fd
|
1.8 MB | Preview Download |
Additional details
- Eprint ID
- 50070
- Resolver ID
- CaltechAUTHORS:20140926-131926805
- Caltech-City of Hope Biomedical Research Initiative
- Caltech Summer Undergraduate Research Fellowship (SURF)
- Created
-
2014-10-09Created from EPrint's datestamp field
- Updated
-
2021-11-10Created from EPrint's last_modified field