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Published June 5, 2014 | Published
Journal Article Open

In Vivo Monitoring of Natural Killer Cell Trafficking During Tumor Immunotherapy

Abstract

Natural killer (NK) cells are a crucial part of the innate immune system and play critical roles in host anti-viral, anti-microbial, and antitumor responses. The elucidation of NK cell biology and their therapeutic use are actively being pursued with 200 clinical trials currently underway. In this review, we outline the role of NK cells in cancer immunotherapies and summarize current noninvasive imaging technologies used to track NK cells in vivo to investigate mechanisms of action, develop new therapies, and evaluate efficacy of adoptive transfer.

Additional Information

© The authors, publisher and licensee Libertas Academica Limited. This is an open-access article distributed under the terms of the Creative Commons CC-BY-NC 3.0 License. Received: February 24, 2014. resubmitted: April 29, 2014. accepted for publication: April 29, 2014. This work was funded in part by NIBIB EB000993 and the Beckman Institute. The authors acknowledge the contributions of Sharon Lin for invaluable assistance with animal- and cell-based work. Drs. Andrew Raubitschek and David Colcher (City of Hope, Duarte CA) provided cogent comments as well as animals and cells for our NK cell studies. Author Contributions: Conceived and designed the experiments: NSSM, SRB, and REJ. Analyzed the data: NSSM and SRB. Wrote the first draft of the manuscript: NSSM. Contributed to the writing of the manuscript: NSSM, SRB, and REJ. Agree with manuscript results and conclusions: NSSM, SRB, and REJ. Jointly developed the structure and arguments for the paper: NSSM, SRB, and REJ. Made critical revisions and approved final version: NSSM, SRB, and REJ. All authors reviewed and approved of the final manuscript.

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August 22, 2023
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