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Published May 7, 2014 | Supplemental Material
Journal Article Open

A wave dynamics criterion for optimization of mammalian cardiovascular system

Abstract

The cardiovascular system in mammals follows various optimization criteria covering the heart, the vascular network, and the coupling of the two. Through a simple dimensional analysis we arrived at a non-dimensional number (wave condition number) that can predict the optimum wave state in which the left ventricular (LV) pulsatile power (LV workload) is minimized in a mammalian cardiovascular system. This number is also universal among all mammals independent of animal size maintaining a value of around 0.1. By utilizing a unique in vitro model of human aorta, we tested our hypothesis against a wide range of aortic compliance (pulse wave velocity). We concluded that the optimum value of the wave condition number remains to be around 0.1 for a wide range of aorta compliance that we could simulate in our in-vitro system.

Additional Information

© 2014 Elsevier Ltd. Accepted 13 February 2014. Niema M. Pahlevan acknowledges support from the American Heart Association (AHA) Predoctoral fellowship (Award Id: 12PRE9610015)

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