Development of functional assays for p97/VCP inhibition

Creators: Shi, Yihui; Liu, Xiaohe; Calaoagan, Joy; Samuelson, Steven; Chou, Tsui-Fen; Deshaies, Raymond J.; Sambucetti, Lidia C.

Abstract

p97 (also called VCP in metazoans and CDC48 in yeast) is a highly conserved, ubiquitously expressed, and essential AAA ATPase. p97 plays a key role in endoplasmic reticulum-associated degradation of misfolded secretory and membrane proteins as well as ubiquitin-dependent turnover of a subset of cytoplasmic substrates of the ubiquitin-proteasome system.

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