Published February 13, 2014
| Accepted Version
Journal Article
Open
Structural Insights on the Role of Antibodies in HIV-1 Vaccine and Therapy
Abstract
Despite 30 years of effort, there is no effective vaccine for HIV-1. However, antibodies can prevent HIV-1 infection in humanized mice and macaques when passively transferred. New single-cell-based methods have uncovered many broad and potent donor-derived antibodies, and structural studies have revealed the molecular bases for their activities. The new data suggest why such antibodies are difficult to elicit and inform HIV-1 vaccine development efforts. In addition to protecting against infection, the newly identified antibodies can suppress active infections in mice and macaques, suggesting they could be valuable additions to anti-HIV-1 therapies and to strategies to eradicate HIV-1 infection.
Additional Information
© 2014 Elsevier Inc. Available online 13 February 2014. We thank Susan Zolla-Pazner for helpful discussions and critical review. This work was supported by a Collaboration for AIDS Vaccine Discovery (CAVD) grant from the Bill and Melinda Gates Foundation (Grant ID: 1040753 to P.J.B. and M.C.N.), National Institutes of Health grant HIVRAD P01 AI100148 (P.J.B. and M.C.N.) and award number DP1OD006961 (to P.J.B.), NIH Center for HIV/AID Vaccine Immunology and Immunogen Discovery (CHAVI-ID) 1UM1 AI100663-01 (M.C.N.), and the American Cancer Society (Grant PF-13-076-01-MPC to L.S.). F.K. was supported by the Stavros Niarchos Foundation.Attached Files
Accepted Version - nihms-568245.pdf
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Additional details
- PMCID
- PMC4041625
- Eprint ID
- 43888
- DOI
- 10.1016/j.cell.2014.01.052
- Resolver ID
- CaltechAUTHORS:20140220-100322233
- Collaboration for AIDS Vaccine Discovery
- Bill and Melinda Gates Foundation
- 1040753
- NIH
- HIVRAD P01 AI100148
- NIH
- DP1OD006961
- NIH
- 1UM1 AI100663-01
- American Cancer Society
- PF-13-076-01-MPC
- Stavros Niarchos Foundation
- Created
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2014-02-20Created from EPrint's datestamp field
- Updated
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2021-11-10Created from EPrint's last_modified field