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Published May 1, 2014 | Published + Accepted Version
Journal Article Open

Sensational placodes: Neurogenesis in the otic and olfactory systems

Abstract

For both the intricate morphogenetic lay out of the sensory cells in the ear and the elegantly radial arrangement of the sensory neurons in the nose, numerous signaling molecules and genetic determinants are required in concert to generate these specialized neuronal populations that help connect us to our environment. In this review, we outline many of the proteins and pathways that play essential roles in the differentiation of otic and olfactory neurons and their integration into their non-neuronal support structures. In both cases, well-known signaling pathways together with region-specific factors transform thickened ectodermal placodes into complex sense organs containing numerous, diverse neuronal subtypes. Olfactory and otic placodes, in combination with migratory neural crest stem cells, generate highly specialized subtypes of neuronal cells that sense sound, position and movement in space, odors and pheromones throughout our lives.

Additional Information

© 2014 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license. Open Access funded by Biotechnology and Biological Sciences Research Council. Available online 6 February 2014. We thank Leila Abbas and Lena Gunhaga for providing images or for permission to use images; Robert Kelsh for the Tg(–4.9sox10:eGFP) line and Yoshihiro Yoshihara, RIKEN BSI, and the National Bioresource Project of Japan for the Tg(TRPC24.5k:gap-Venus)/rw037 and Tg(OMP2k:lyn-mRFP)/rw035 lines that are featured in the figures. ECM was funded by a Marie Curie Intra European Fellowship (275978). This work was supported by the following grants: BFU2001-27006 to BA, NIH grants DE16459 and DC011577 to MEB, and a BBSRC project grant BB/J003050 to TTW.

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Published - Maier_et_al.,_2014.pdf

Accepted Version - 1-s2.0-S0012160614000517-main.pdf

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August 22, 2023
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