Feed Your Head: Neurodevelopmental Control of Feeding and Metabolism
- Creators
- Lee, Daniel A.
- Blackshaw, Seth
Abstract
During critical periods of development early in life, excessive or scarce nutritional environments can disrupt the development of central feeding and metabolic neural circuitry, leading to obesity and metabolic disorders in adulthood. A better understanding of the genetic networks that control the development of feeding and metabolic neural circuits, along with knowledge of how and where dietary signals disrupt this process, can serve as the basis for future therapies aimed at reversing the public health crisis that is now building as a result of the global obesity epidemic. This review of animal and human studies highlights recent insights into the molecular mechanisms that regulate the development of central feeding circuitries, the mechanisms by which gestational and early postnatal nutritional status affects this process, and approaches aimed at counteracting the deleterious effects of early over-and underfeeding.
Additional Information
© 2014 Annual Reviews. Review in Advance first posted online on November 18, 2013. We thank W. Yap, T. Moran, and J. Bedont for helpful feedback on the manuscript.Attached Files
Accepted Version - nihms591249.pdf
Files
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Additional details
- PMCID
- PMC4512170
- Eprint ID
- 42810
- Resolver ID
- CaltechAUTHORS:20131203-153902408
- Created
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2013-12-11Created from EPrint's datestamp field
- Updated
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2021-11-10Created from EPrint's last_modified field