Engineering an HIV Envelope Protein to Activate Germline B Cell Receptors of Broadly Neutralizing VRC01-Class Antibodies
Abstract
The recent RV144 trial showed ~30% efficacy. Although the protection was modest, the trial indicated for the first time that a vaccine against HIV is possible. Immune correlate analysis suggests that the observed protection was due to non-neutralizing antibody responses. This efficacy might be improved if a vaccine could elicit broadly neutralizing antibodies (bNAbs). Of particular interest for vaccine design are the potent VRC01- class bNAbs targeting CD4 binding site on Env. Unfortunately, a number of studies have demonstrated that recombinant Env proteins do not bind germline-reverted VRC01 class Abs, indicating that current vaccine strategies using recombinant Env are unable to activate progenitor B cells that ultimately give rise to VRC01 class Abs.
Additional Information
© 2013 Mary Ann Liebert, Inc. publishers. Published in Volume: 29 Issue 11: October 24, 2013. Online Ahead of Print: October 10, 2013.Attached Files
Published - McGuire_2013pA6.pdf
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Additional details
- Eprint ID
- 42641
- DOI
- 10.1089/aid.2013.1500
- Resolver ID
- CaltechAUTHORS:20131122-084031728
- Created
-
2013-11-24Created from EPrint's datestamp field
- Updated
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2021-11-10Created from EPrint's last_modified field