Feasibility Study of Carbon Nanotube Microneedles for Rapid Transdermal Drug Delivery
Abstract
We introduce a new approach for fabricating hollow microneedles using vertically-aligned carbon nanotubes (VA-CNTs) for rapid transdermal drug delivery. Here, we discuss the fabrication of the microneedles emphasizing the overall simplicity and flexibility of the method to allow for potential industrial application. By capitalizing on the nanoporosity of the CNT bundles, uncured polymer can be wicked into the needles ultimately creating a high strength composite of aligned nanotubes and polymer. Flow through the microneedles as well as in vitro penetration of the microneedles into swine skin is demonstrated. Furthermore, we present a trade study comparing the difficulty and complexity of the fabrication process of our CNT-polymer microneedles with other standard microneedle fabrication approaches.
Additional Information
© 2013 Materials Research Society. We acknowledge Zcube s.r.l for their financial support of this work. We also acknowledge the Kavli Nanoscience Institute and the Geology and Planetary Sciences Analytical Facility for their support in running experiments.Attached Files
Published - Lyon_et_al-_Feasibility_Study_of_CNT_Microneedles.pdf
Files
Name | Size | Download all |
---|---|---|
md5:b5d8d187f670ff4c66f33142eead0078
|
553.3 kB | Preview Download |
Additional details
- Eprint ID
- 42516
- Resolver ID
- CaltechAUTHORS:20131118-091418305
- Zcube s.r.l.
- Created
-
2013-11-18Created from EPrint's datestamp field
- Updated
-
2023-03-14Created from EPrint's last_modified field
- Caltech groups
- Kavli Nanoscience Institute, GALCIT