WormBase 2014: new views of curated biology
Abstract
WormBase (http://www.wormbase.org/) is a highly curated resource dedicated to supporting research using the model organism Caenorhabditis elegans. With an electronic history predating the World Wide Web, WormBase contains information ranging from the sequence and phenotype of individual alleles to genome-wide studies generated using next-generation sequencing technologies. In recent years, we have expanded the contents to include data on additional nematodes of agricultural and medical significance, bringing the knowledge of C. elegans to bear on these systems and providing support for underserved research communities. Manual curation of the primary literature remains a central focus of the WormBase project, providing users with reliable, up-to-date and highly cross-linked information. In this update, we describe efforts to organize the original atomized and highly contextualized curated data into integrated syntheses of discrete biological topics. Next, we discuss our experiences coping with the vast increase in available genome sequences made possible through next-generation sequencing platforms. Finally, we describe some of the features and tools of the new WormBase Web site that help users better find and explore data of interest.
Additional Information
© 2013 The Author(s). Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. Received October 10, 2013; Accepted October 12, 2013. First published online: November 4, 2013. The US National Human Genome Research Institute [U41-HG002223] to WormBase and British Medical Research Council [G070119] to WormBase; P.W.S. is an investigator with the Howard Hughes Medical Institute. Funding for open access charge: US National Human Genome Research Institute [U41-HG002223]. Conflict of interest statement. None declared.Attached Files
Published - Harris_2013.pdf
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Additional details
- PMCID
- PMC3965043
- Eprint ID
- 42405
- Resolver ID
- CaltechAUTHORS:20131112-152912465
- NIH
- U41-HG002223
- Medical Research Council (UK)
- G070119
- Created
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2013-11-13Created from EPrint's datestamp field
- Updated
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2021-11-10Created from EPrint's last_modified field