Extracellular field signatures of CA1 spiking cell assemblies during sharp wave-ripple complexes

Abstract

Although postsynaptic and transmembrane currents over local neuronal populations are considered the main factors for shaping local field potential (LFP) and current source density (CSD) fluctuations [1], high-frequency oscillatory LFPs can also be shaped by extracellular action potentials of pyramidal cell populations [2]. Sharp wave-ripple complexes (SWRs) are typical examples of such high-frequency oscillatory events, observed in hippocampal LFPs during deep sleep and awake immobility. They consist of an extensive depolarization in the CA1 dendritic layer (sharp wave) arising from population bursts in CA3, accompanied by a ~150-200 Hz LFP oscillation in the CA1 pyramidal layer (ripple). During SWRs, temporal firing patterns of correlated place cells, acquired during wakeful exploration, are replayed in fast-scale, providing a strong indication for the participation of SWRs in memory consolidation. Yet the particular effects of these pattern replays on the hippocampal extracellular field are largely unknown. How are the different ensembles of spiking cells encoded in the emerging ripple-LFPs? Here, we study this association through both a modeling and an experimental approach.

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