Intraduplex DNA-Mediated Electrochemistry of Covalently Tethered Redox-Active Reporters
- Creators
- Pheeney, Catrina G.
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Barton, Jacqueline K.
Abstract
Intraduplex DNA-mediated reduction is established as a general mechanism for the reduction of distally bound stacked redox-active species covalently tethered to DNA through flexible alkane linkages. Methylene Blue (MB), Nile Blue (NB), and Anthraquinone (AQ) were covalently tethered to DNA with three different covalent linkages. Using these reporters DNA electrochemistry was shown to be both DNA-mediated and intra-, rather than inter-, duplex. Significantly, the charge transport pathway occurring through the DNA π-stack is established by using an intervening AC mismatch to break this path. The fact that the DNA-mediated reduction of MB occurs primarily via intraduplex intercalation is established through varying the proximity and integrity of the neighboring duplex DNA.
Additional Information
© 2013 American Chemical Society. Publication Date (Web): September 30, 2013. Received: August 6, 2013. We are grateful for the support of NIH (GM61077). We also thank the Kavli Nanoscience Institute facilities and staff for help in fabricating the multiplexed chips. The authors declare no competing financial interest.Attached Files
Accepted Version - nihms540465.pdf
Supplemental Material - ja408135g_si_001.pdf
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Additional details
- PMCID
- PMC3899830
- Eprint ID
- 42255
- Resolver ID
- CaltechAUTHORS:20131105-140620927
- GM61077
- NIH
- Created
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2013-11-05Created from EPrint's datestamp field
- Updated
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2021-11-10Created from EPrint's last_modified field
- Caltech groups
- Kavli Nanoscience Institute