Welcome to the new version of CaltechAUTHORS. Login is currently restricted to library staff. If you notice any issues, please email coda@library.caltech.edu
Published October 2013 | Accepted Version + Supplemental Material
Journal Article Open

High carbohydrate–low protein consumption maximizes Drosophila lifespan

Abstract

Dietary restriction extends lifespan in a variety of organisms, but the key nutritional components driving this process and how they interact remain uncertain. In Drosophila, while a substantial body of research suggests that protein is the major dietary component affecting longevity, recent studies claim that carbohydrates also play a central role. To clarify how nutritional factors influence longevity, nutrient consumption and lifespan were measured on a series of diets with varying yeast and sugar content. We show that optimal lifespan requires both high carbohydrate and low protein consumption, but neither nutrient by itself entirely predicts lifespan. Increased dietary carbohydrate or protein concentration does not always result in reduced feeding—the regulation of food consumption is best described by a constant daily caloric intake target. Moreover, due to differences in food intake, increased concentration of a nutrient within the diet does not necessarily result in increased consumption of that particular nutrient. Our results shed light on the issue of dietary effects on lifespan and highlight the need for accurate measures of nutrient intake in dietary manipulation studies.

Additional Information

© Elsevier Inc. Received 20 August 2012. Received in revised form 12 December 2012. Accepted 4 February 2013. Available online 10 February 2013. Section Editor: Christiaan Leeuwenburgh. This work was supported by grants from the National Institutes of Health (1R15AG027749, T.B.; R01 AG031337 and AG038012, P.K.; and R00AG030493 and R21DK092735, W.W.J.), National Science Council (NSC 100-2311-B-007-006, H.-D.W.), The Ellison Medical Foundation (P.K. and W.W.J.), and the Glenn Foundation for Medical Research/American Federation for Aging Research (P.K. and W.W.J.).

Attached Files

Accepted Version - nihms445952.pdf

Supplemental Material - mmc1.doc

Files

nihms445952.pdf
Files (1.7 MB)
Name Size Download all
md5:a9abeb25c51480672572cb4a874e365b
52.2 kB Download
md5:da498b1e236b890133b0d5528838d08c
1.7 MB Preview Download

Additional details

Created:
August 22, 2023
Modified:
October 24, 2023