A Biophysically Detailed Model of Neocortical Local Field Potentials Predicts the Critical Role of Active Membrane Currents
Abstract
Brain activity generates extracellular voltage fluctuations recorded as local field potentials (LFPs). It is known that the relevant microvariables, the ionic currents across membranes, jointly generate the macrovariables, the extracellular voltage, but neither the detailed biophysical knowledge nor the required computational power have been available to model these processes. We simulated the LFP in a model of the rodent neocortical column composed of >12,000 reconstructed, multicompartmental, and spiking cortical layer 4 and 5 pyramidal neurons and basket cells, including five million dendritic and somatic compartments with voltage- and ion-dependent currents, realistic connectivity, and probabilistic AMPA, NMDA, and GABA synapses. We found that, depending on a number of factors, the LFP reflects local and cross-layer processing. Active currents dominate the generation of LFPs, not synaptic ones. Spike-related currents impact the LFP not only at higher frequencies but below 50 Hz. This work calls for re-evaluating the genesis of LFPs.
Additional Information
© 2013 Elsevier Under an Elsevier user license. Accepted: May 16, 2013; Published: July 24, 2013. This work was supported by the National Institute of Neurological Disorders and Stroke, Human Frontier Science Program, Swiss National Science Foundation, the Allen Institute for Brain Science, and the Mathers Charitable Foundation and by funding to the Blue Brain Project by the ETH Board and EPFL. Financial support for the CADMOS Blue Gene/P system was provided by the Canton of Geneva, Canton of Vaud, Hans Wilsdorf Foundation, Louis-Jeantet Foundation, University of Geneva, University of Lausanne, and EPFL. Special thanks goes to G. Buzsáki, E. Schomburg, A. Shai, Y. Billeh, J. Taxidis, and members of the Blue Brain Consortium, in particular, Michael Hines, James King, Eilif Muller, Srikant Ramaswamy, Felix Schürmann, and Werner van Geit.Attached Files
Accepted Version - nihms-483616.pdf
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Additional details
- PMCID
- PMC3732581
- Eprint ID
- 41046
- DOI
- 10.1016/j.neuron.2013.05.023
- Resolver ID
- CaltechAUTHORS:20130903-094008150
- NIH
- Human Frontier Science Program
- Swiss National Science Foundation (SNSF)
- Allen Institute for Brain Science
- G. Harold & Leila Y. Mathers Foundation
- ETH Board
- École Polytechnique Fédérale de Lausanne (EPFL)
- Canton of Geneva
- Canton of Vaud
- Hans Wilsdorf Foundation
- Louis-Jeantet Foundation
- University of Geneva
- University of Lausanne
- Created
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2013-09-16Created from EPrint's datestamp field
- Updated
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2021-11-10Created from EPrint's last_modified field