Published March 12, 2004
| public
Journal Article
Minimal Functional Model of Hemostasis in a Biomimetic Microfluidic System
Chicago
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Abstract
The proof of the model is in the function: A minimal model of hemostasis (a complex biochemical network responsible for blood coagulation) may be implemented with only three chemical reactions, which creates a biomimetic functional microfluidic system that is capable of repairing itself (as modeled in the figure). This simple system shows threshold response and sensitivity to flow similar to that observed in hemostasis.
Additional Information
Copyright © 2004 WILEY-VCH. Issue published online: 9 MAR 2004. Article first published online: 24 FEB 2004. Manuscript Received: 28 NOV 2003. This work was supported by NSF CAREER Award, Office of Naval Research Young Investigator Award (N00014-03-10482), Searle Scholars Program, and by Dreyfus New Faculty Award. We thank Professors G. M. Whitesides, C. Chen, C. Hall, T. Van Ha, V. Turitto, and M. LaBarbera for invaluable suggestions.Additional details
- Eprint ID
- 40859
- DOI
- 10.1002/anie.200353428
- Resolver ID
- CaltechAUTHORS:20130821-160729811
- NSF CAREER
- ONR
- N00014-03-10482
- Searle Scholars Program
- Camille and Henry Dreyfus Foundation
- Created
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2013-08-28Created from EPrint's datestamp field
- Updated
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2021-11-10Created from EPrint's last_modified field