A physical organic mechanistic approach to understanding the complex reaction network of hemostasis (blood clotting)
Abstract
This review focuses on how the mechanistic approach of physical organic chemistry can be used to elucidate the mechanisms behind complex biochemical networks. The dynamics of biochemical reaction networks is difficult to describe by considering their individual reactions, just as the dynamics of organic reactions is difficult to describe by considering individual electrons and atomic nuclei. Physical organic chemists have developed a useful set of tools to predict the outcome of organic reactions by separating the interacting molecules into modules (functional groups), and defining general rules for how these modules interact (mechanisms). This review shows how these tools of physical organic chemistry may be used to describe reaction networks. In addition, it describes the application of these tools to develop a mechanistic understanding of the dynamics of the complex network of hemostasis, which regulates blood clotting.
Additional Information
Copyright © 2007 John Wiley & Sons. Received 17 April 2007; revised 14 June 2007; accepted 18 June 2007. This work was supported in part by NSF CAREER Award CHE-0349034, ONR Grant N00014-03-10482, and by the Dreyfus Teacher-Scholar Award. R.F.I. is a Cottrell Scholar of Research Corporation, and an A. P. Sloan Research Fellow. Some of this work was performed at the MRSEC microfluidic facility funded by the NSF. We thank Matthew Runyon for helpful discussions and Jessica M. Price for assistance in editing and writing this manuscript.Additional details
- Eprint ID
- 40806
- Resolver ID
- CaltechAUTHORS:20130821-160720940
- CHE-0349034
- NSF
- N00014-03-10482
- ONR
- Camille and Henry Dreyfus Foundation
- Cottrell Scholar of Research Corporation
- Alfred P. Sloan Foundation
- Created
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2013-08-27Created from EPrint's datestamp field
- Updated
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2021-11-10Created from EPrint's last_modified field