Visual Motion Area MT+/V5 Responds to Auditory Motion in Human Sight-Recovery Subjects
Abstract
Using functional magnetic resonance imaging, we found that cortical visual motion area MT+/V5 responded to auditory motion in two rare subjects who had been blind since early childhood and whose vision was partially recovered in adulthood. Visually normal control subjects did not show similar auditory responses. These auditory responses in MT+ were specific to motion compared with other complex auditory stimuli including frequency sweeps and speech. Thus, MT+ developed motion-specific responses to nonvisual input, suggesting that cross-modal plasticity can be influenced by the normal functional specialization of a cortical region. Regarding sight recovery after early blindness, our results further demonstate that cross-modal responses coexist with regained visual responses within the visual cortex.
Additional Information
Received Nov. 27, 2007; revised March 25, 2008; accepted March 26, 2008. This work was supported by the Gordon and Betty Moore Foundation, the Mind Science Foundation, the Caltech Summer Undergraduate Research Fellowships program, the National Institutes of Health, and the National Science Foundation. We thank our study participants, in particular M.M. and M.S., and also thank Ulrik Beierholm for help with the sparse MRI pulse sequence design.Attached Files
Published - Saenz-et-al-08.pdf
Supplemental Material - JNeuro_SuppFigures_Page_1.gif
Supplemental Material - JNeuro_SuppFigures_Page_2.gif
Supplemental Material - JNeuro_SuppFigures_Page_3.gif
Supplemental Material - JNeuro_SupplementaryTable.pdf
Supplemental Material - Supplemental_Figure_Legends.pdf
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Additional details
- PMCID
- PMC3165167
- Eprint ID
- 40653
- Resolver ID
- CaltechAUTHORS:20130816-103349452
- Gordon and Betty Moore Foundation
- Mind Science Foundation
- Caltech Summer Undergraduate Research Fellowship Program
- National Institutes of Health
- National Science Foundation
- Created
-
2008-05-16Created from EPrint's datestamp field
- Updated
-
2021-11-10Created from EPrint's last_modified field
- Caltech groups
- Koch Laboratory (KLAB)