Luminescent probes for DNA base mismatches

Abstract

Mismatch repair deficiency has been implicated in a no. of diseases, such as cancer, and DNA base mismatches accumulate when mismatch repair pathways are defective. The metal complex [Rh(bpy)2(chrysi)]3+ has been shown to be selective for DNA base mismatches due to the sterically expansive chrysi ligand, and there is interest in developing a luminescent analog for diagnosing mismatch repair deficiencies. The complex [Ru(bpy)2(dppz)]2+ is a light switch for DNA and shows enhanced luminescence in the presence of DNA defects. In an effort to improve the luminescence response for mismatched over matched DNA, a new family of ruthenium(II) complexes has been prepd. with sterically expansive ligands and their luminescence responses to DNA defects have been investigated.

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