Published July 15, 1977
| public
Journal Article
Mechanism of carbon isotope fractionation associated with lipid synthesis
- Creators
- DeNiro, Michael J.
- Epstein, Samuel
Abstract
The low carbon-13/carbon-12 ratio of lipids is shown to result from isotopic fractionation during the oxidation of pyruvate to acetyl coenzyme A. In vitro analysis of the kinetic isotope effects of this reaction indicates that there will be a large, temperature-dependent difference in the carbon-13/carbon-12 ratio between the methyl and carbonyl carbon atoms of acetyl coenzyme A and between those carbon atoms of lipid components which derive from them.
Additional Information
© 1977 American Association for the Advancement of Science. Received 10 January 1977; revised 14 March 1977. Supported by NSF grant DES71-00558 A03. This is contribution No. 2854, Division of Geological and Planetary Sciences, California Institute of TechnologyAdditional details
- Eprint ID
- 39227
- Resolver ID
- CaltechAUTHORS:20130703-132744091
- DES71-00558 A03
- NSF
- Created
-
2013-07-09Created from EPrint's datestamp field
- Updated
-
2023-06-02Created from EPrint's last_modified field
- Other Numbering System Name
- Caltech Division of Geological and Planetary Sciences
- Other Numbering System Identifier
- 2854