Published May 17, 2013
| Accepted Version + Supplemental Material
Journal Article
Open
High-Throughput Screening for Terpene-Synthase-Cyclization Activity and Directed Evolution of a Terpene Synthase
Chicago
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Abstract
The development of high-throughput assays can be extremely challenging, yet is essential for many applications in drug discovery and enzyme engineering.
Additional Information
© 2013 Wiley-VCH Verlag GmbH & Co. Received: February 15, 2013; Published online: March 26, 2013. We are grateful to David Cane, Scott Virgil, Robert M. Coates, and David Christianson for their pioneering studies, invaluable advice, encouragement, and materials. We thank Indira Wu, Chris Farwell, and Jack Zhang for assistance. R.L. acknowledges the support of NIH fellowship F32GM095061. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. K.S.R. thanks the Deutscher Akademischer Austauschdienst (DAAD) for a postdoctoral fellowship. K.Z.K. and R.Z.K. acknowledge the support of Summer Undergraduate Research Fellowships from the California Institute of Technology. T.H. was funded by the FWF grant number: J3327-B21.Attached Files
Accepted Version - nihms523186.pdf
Supplemental Material - Supporting_Information.pdf
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Supporting_Information.pdf
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Additional details
- Alternative title
- High-throughput screening and directed evolution of terpene synthase-catalyzed cylization
- PMCID
- PMC3828198
- Eprint ID
- 39162
- Resolver ID
- CaltechAUTHORS:20130701-105908055
- NIH
- F32GM095061
- Deutscher Akademischer Austauschdienst (DAAD)
- Caltech Summer Undergraduate Research Fellowship (SURF)
- FWF Der Wissenschaftsfonds
- J3327-B21
- Created
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2013-07-01Created from EPrint's datestamp field
- Updated
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2021-11-09Created from EPrint's last_modified field