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Published April 16, 2013 | Accepted Version
Journal Article Open

The Cation-π Interaction

Abstract

The chemistry community now recognizes the cation−π interaction as a major force for molecular recognition, joining the hydrophobic effect, the hydrogen bond, and the ion pair in determining macromolecular structure and drug–receptor interactions. This Account provides the author's perspective on the intellectual origins and fundamental nature of the cation−π interaction.

Additional Information

© 2012 American Chemical Society. Received on September 10, 2012. Published In Issue April 16, 2013. Article ASAP December 07, 2012. Publication Date (Web): December 7, 2012. We thank the NIH for financial support. We also gratefully acknowledge the many students, postdoctoral associates, and collaborators who contributed immeasurably to this work. The authors declare no competing financial interest.

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