Published June 18, 2004
| public
Book Section - Chapter
Antibodies Against Huntingtin: Production and Screening of Monoclonals and Single-Chain Recombinant Forms
- Creators
- Khoshnan, Ali
- Ou, Susan
- Ko, Jan
- Patterson, Paul H.
- Other:
- Kohwi, Yoshinori
Chicago
An error occurred while generating the citation.
Abstract
Antibodies can be extremely useful tools for the field of triplet repeat diseases. These reagents are important for localizing proteins in tissues, and within cells, they can be used in the isolation and characterization of the components of protein complexes, they can distinguish proteins with normal or an expanded polyglutamine repeat, they may be able to distinguish distinct conformations of a protein, and they can be used to perturb the function of proteins in living cells. Our group has produced monoclonal and recombinant single-chain antibodies that can be used for each of these purposes with huntingtin. This is the protein that, when mutated to contain an expanded polyQ motif, causes Huntington's disease.
Additional Information
© 2004 Humana Press Inc. Work cited from the authors' laboratory was supported by the Hereditary Disease Foundation.Additional details
- Alternative title
- Antibodies Against Huntingtin - Production and Screening of Monoclonals and Single-Chain Recombinant Forms
- Eprint ID
- 38974
- DOI
- 10.1385/1-59259-804-8:087
- Resolver ID
- CaltechAUTHORS:20130618-141957582
- Hereditary Disease Foundation
- Created
-
2013-06-24Created from EPrint's datestamp field
- Updated
-
2021-11-09Created from EPrint's last_modified field
- Series Name
- Methods in Molecular Biology
- Series Volume or Issue Number
- 277