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Published April 9, 2013 | Published
Journal Article Open

Regulation of zebrafish sleep and arousal states: current and prospective approaches

Abstract

Every day, we shift among various states of sleep and arousal to meet the many demands of our bodies and environment. A central puzzle in neurobiology is how the brain controls these behavioral states, which are essential to an animal's well-being and survival. Mammalian models have predominated sleep and arousal research, although in the past decade, invertebrate models have made significant contributions to our understanding of the genetic underpinnings of behavioral states. More recently, the zebrafish has emerged as a promising model system for sleep and arousal research. Here we review experimental evidence that the zebrafish, a diurnal vertebrate, exhibits fundamental behavioral and neurochemical characteristics of mammalian sleep and arousal. We also propose how specific advantages of the zebrafish can be harnessed to advance the field. These include tractable genetics to identify and manipulate molecular and cellular regulators of behavioral states, optical transparency to facilitate in vivo observation of neural structure and function, and amenability to high-throughput drug screens to discover novel therapies for neurological disorders.

Additional Information

© 2013 Chiu and Prober. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc. Received: 07 February 2013; Paper pending published: 03 March 2013; Accepted: 14 March 2013; Published online: 09 April 2013. This work was supported by grants from the National Institutes of Health (R00 NS060996, R01 NS070911 and R01 DA031367), and the Edward Mallinckrodt Jr., Rita Allen and Brain and Behavior Research Foundations.

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Created:
August 19, 2023
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October 23, 2023