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Published May 2013 | Accepted Version
Journal Article Open

The Yin and Yang of microRNAs: leukemia and immunity

Abstract

Yin and Yang are two complementary forces that together describe the nature of real-world elements. Yin is the dark side; Yang is the light side. We describe microRNAs having both Yin and Yang characteristics because they can contribute to normal function (Yang) but also to autoimmunity, myeloproliferation, and cancer (Yin). We have been working on a number of microRNAs that have these dual characteristics and here we focus on two, miR-125b and miR-146a. We have concentrated on these two RNAs because we have very extensive knowledge of them, much of it from our laboratory, and also because they provide a strong contrast: the effects of overexpression of miR-125b are rapid, suggesting that it acts directly, whereas the effects of miR-146a are slow to develop, suggesting that they arise from chronic alterations in cellular behavior.

Additional Information

© 2013 John Wiley & Sons A/S. Published by Blackwell Publishing Ltd. Article first published online: 2 Apr. 2013. This work was supported by NIH grants 5P01CA132681-02, 5R01AI093531-02, an Ellison Foundation award to D. B., and F32 CA139883 to A. Y. S. J. L. Z. was supported by the UCLA/Caltech Joint Medical Scientist Training Program and National Research Service Award F30HL110691 from the National Institute of Health. The authors have no conflicts of interest to declare.

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Created:
August 22, 2023
Modified:
October 23, 2023